Published Date： 2017-06-13
Hong-Mei Jia 
Professor and Supervisor for Ph.D. candidates, Ph. D. (Beijing Normal University), visiting scholar in Yale University, USA, visiting scholar and senior visiting scholar in Institute of Interdisciplinary Isotope Research, Leipzig, Germany, and senior visiting fellow in Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
Postal address: College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China
Phone: +86-10-5880 8891
Fax: +86-10-5880 8891
E-mail：hmjia@bnu.edu.cn
Teaching
Radiopharmaceutical Chemistry, and General Chemistry Experiment.
Research Interests
Radiopharmaceutical chemistry, Development of new radiotracers and radiopharmaceuticals for imaging of biological functions.
Grants and research support
- Current grants
Agency: National Natural Science Foundation of China (NSFC)
Grant No.: 21471019
Title: Investigation of Tc-99m/Re-188 labeled σ2 receptor radiopharmaceuticals for tumor imaging and therapy
P.I.: Hongmei Jia
Project period: January 2015―December 2018
- Past grants
Agency: National Natural Science Foundation of China (NSFC)
Grant No.: 21071023
Title: Investigation of Tc-99m labeled σ2 receptor molecular probes for tumor imaging agents
P.I.: Hongmei Jia
Project period: January 2011―December 2013
Agency: National Natural Science Foundation of China (NSFC)
Grant No.: 20501004
Title: Investigation of Tc-99m labeled σ receptor complexes for tumor imaging agents
P.I.: Hongmei Jia
Project period: January 2006―December 2008
Agency: State Education Ministry, P. R. China
Grant type: Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
Title: Reductive etherification reaction and its applications in the synthesis of F-18 labeled radiopharmaceuticals for PET imaging
P.I.: Hongmei Jia
Project period: 2004―2006
Invention Patents
- Jia Hongmei, Wang Xia, Li Dan, Cui Mengchao, Liu Boli. Synthesis and applications of cyclopentadienyl tricarbonyl 99mTc/Re complexes as sigma-1 receptor ligands. State Intellectual Property Office of the People’s Republic of China. ZL 2013 1 0339656.1 (Chinese), April 6, 2016.
- Jia Hongmei, Li Yan, Zhang Jinming, Cui Mengchao, Liu Boli. Synthesis and applications of 18F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands. State Intellectual Property Office of the People’s Republic of China. ZL 2012 1 0097119.6 (Chinese), October 8, 2014.
Representative papers
- He Yingfang, Xie Fang, Ye Jiajun, Deuther-Conrad Winnie, Cui Bixiao, Wang Liang, Lu Jie, Steinbach Jörg, Brust Peter, Huang Yiyun, Lu Jie*, Jia Hongmei*. 1-(4-[18F]Fluorobenzyl)-4-((tetrahydrofuran-2-yl)methyl)piperazine: A novel suitable radioligand with low lipophilicity for imaging σ1 receptors in the brain. Journal of Medicinal Chemistry, 2017, 60: 4161-4172.
- Li Dan, Chen Yuanyuan, Wang Xia, Deuther-Conrad Winnie, Chen Xin, Jia Bing, Dong Chengyan, Steinbach Jörg, Brust Peter, Liu Boli, Jia Hongmei*. 99mTc-cyclopentadienyl tricarbonyl chelate-labeled compounds as selective sigma-2 receptor ligands for tumor imaging. Journal of Medicinal Chemistry, 2016, 59: 934-946.
- Xie Fang, Bergmann Ralf, Kniess Torsten, Deuther-Conrad Winnie, Mamat Constantin, Neuber Christin, Liu Boli, Steinbach Jörg, Brust Peter, Pietzsch Jens, Jia Hongmei*.18F-labeled 1,4-dioxa-8-azaspiro[4.5]decane derivative: synthesis and biological evaluation of a s1 receptor radioligand with low lipophilicity as potent tumor imaging agent. Journal of Medicinal Chemistry, 2015, 58, 5395-5407.
- Wang Xia, Li Dan, Deuther-Conrad Winnie, Lu Jie, Xie Ying, Jia Bing, Cui Mengchao, Steinbach Jörg, Brust Peter, Liu Boli, Jia Hongmei*. Novel cyclopentadienyl tricarbonyl 99mTc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors. Journal of Medicinal Chemistry, 2014, 57, 7113-7125.
- Li Yan, Wang Xia, Zhang Jinming, Deuther-Conrad Winniw, Xie Fang, Zhang Xiaojun, Liu Jian, Qiao Jinping, Cui Mengchao, Steinbach Joerg, Brust Peter, Liu Boli, Jia Hongmei*. Synthesis and evaluation of novel 18F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands for positron emission tomography imaging. Journal of Medicinal Chemistry, 2013, 56, 3478-3491.
- Wang Liang, Ye Jiajun, He Yingfang, Deuther-Conrad Winnie, Zhang Jinming, Zhang Xiaojun, Cui Mengchao*, Steinbach Jörg, Huang Yiyun, Brust Peter, Jia Hongmei*. 18F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain. Bioorganic & Medicinal Chemistry, 2017, 25: 3792–3802.
- Xie Fang, Kniess Torsten, Neuber Christin, Deuther-Conrad Winnie, Mamat Constantin, Lieberman Brian P., Liu Boli, Mach Robert H., Brust Peter, Steinbach Jörg, Pietzsch Jens, Jia Hongmei*. Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity. MedChemComm, 2015, 6, 1093-1103.
- Chen Yuan-Yuan, Wang Xia, Zhang Jin-Ming, Deuther-Conrad Winnie, Zhang Xiao-Jun, Huang Yiyun, Li Yan, Ye Jia-Jun, Cui Meng-Chao, Steinbach Joerg, Brust Peter, Liu Bo-Li, Jia Hong-Mei*. Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising s1 receptor imaging agent. Bioorganic & Medicinal Chemistry, 2014, 22: 5270–5278.
- Wang Xia, Li Yan, Deuther-Conrad Winnie, Xie Fang, Chen Xin, Cui Meng-Chao, Zhang Xiao-Jun, Zhang Jin-Ming, Steinbach Jörg, Brust Peter, Liu Bo-Li, Jia Hong-Mei*. Synthesis and biological evaluation of 18F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging. Bioorganic & Medicine Chemistry 2013, 21: 215-222.
- Chen Xin, Cui Meng-Chao, Deuther-Conrad Winnie, Tu Ying-Feng, Ma Teng, Xie Ying, Jia Bing, Li Yan, Xie Fang, Wang Xia, Steinbach Jörg, Brust Peter, Liu Bo-Li, Jia Hong-Mei*. Synthesis and biological evaluation of a novel 99mTc cyclopentadienyl tricarbonyl complex ([(Cp-R)99mTc(CO)3]) for sigma-2 receptor tumor imaging. Bioorganic & Medicinal Chemistry Letters 2012, 22: 6352-6357.
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