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    The current position: Organic Chemistry
Xing Guo-Wen

Published Date： 2016-02-28

Xing Guo-Wen

Xing Guo-Wen 中文

Professor and Supervisor for Ph.D. candidates, Ph. D (Peking University), Postdoctor (Shanghai Institute of Organic Chemistry, CAS, Polytechnic University, The Scripps Research Institute)

Postal address: College of Chemistry, Beijing Normal University, Beijing, 100875, China
E-mail: gwxing@bnu.edu.cn
Group homepage: http://xingguowen.chem.bnu.edu.cn/

 

Teaching

Fundamental Organic Chemistry (II), Comprehensive Chemistry Experiment, Asymmetric Synthesis

 

Research Interests

Sialic acid chemistry and fluorescent probes

Representative papers

    1.         Xiao-tai Zhang, Shu Wang, Guo-wen Xing* Novel Boronlectins Based on Bispyridium Salt with a Flexible Linker: Discriminative Sensing of Lactose and Other Monosaccharides and Disaccharides in Aqueous Solution, Chem. Asian J., 2015, DOI: 10.1002/asia.201500743.

    2.         Hongyan Shen, Mingrui An, Xiao Zou, Xuyang Zhao, Qingsong Wang*, Guowen Xing* Jianguo Ji* Evaluation of the accuracy of protein quantification using isotope TMPP-labeled peptides, Proteomics, 2015, DOI 10.1002/pmic.201400495.

    3.         Xiao-tai Zhang, Zhen-yuan Gu, Libing Liu, Shu Wang, Guo-wen Xing* Synthesis and labeling of a-(2,9)-trisialic acid with cyanine dyes for imaging of glycan-binding receptors on living cells, Chem. Commun., 2015, 51, 8606-8609.

    4.         Guang-jian Liu, Xiao-tai Zhang, Guo-wen Xing* A general method for N-glycosylation of nucleobases promoted by (p-Tol)2SO/Tf2O with thioglycoside as donor, Chem. Comm., 2015, DOI: 10.1039/C5CC03617H.

    5.         Qinchao Xu, Can Jin, Xuehui Zhu, Guo-wen Xing* Recent Progress in Fluorescent Probes for Pyrophosphate Based on Small Organic Molecules, Chin. J. Org. Chem., 2014, 34(4), 647-661.

    6.         Xiao-tai Zhang, Zhen-yuan Gu, Guo-wen Xing* Comparative studies on the O-sialylation with four different alpha/beta-oriented (N-acetyl)-5-N,4-O-carbonyl-protected p-toluenethiosialosides as donors, Carbohydr. Res., 2014, 388, 1-7.

    7.         Qin-chao Xu, Hai-juan Lv, Zi-qi Lv, Min Liu, Yang-jie Li, Xiang-feng Wang, Yuan Zhang, Guo-wen Xing* A pyrene-functionalized Zinc(II)-BPEA complex: sensing and discrimination of ATP, ADP and AMP, RSC Adv., 2014, 4(88), 47788-47792.

    8.         Qin-Chao Xu, Xue-Hui Zhu, Can Jin, Guo-Wen Xing*, Yuan Zhang* Dual off-on and on-off fluorescent detection of Zn2+/Cd2+ ions based on carbazolone substituted 2-aminobenzamides, RSC Adv., 2014, 4(7), 3591-3596.

    9.         Zhen-yuan Gu, Xiao-tai Zhang, Jia-xin Zhang, Guo-wen Xing* Highly efficient alpha-C-sialylation promoted by (p-Tol)2SO/Tf2O with N-Acetyl-5-N,4-O-oxazolidione protected thiosialoside as donor. Org. Biomol. Chem., 2013, 11 (30), 5017–5022.

    10.     Qin-chao Xu, Xiang-feng Wang, Guo-wen Xing*, Yuan Zhang* Carbazole Substituted 2-Aminobenzamide Compounds: Synthesis, Fluorescence ON-OFF-ON Sensing of Zn(II) and PPi Ions, Assay for Alkaline Phosphatase, and Computational Study. RSC Adv., 2013, 3, 15834-15841.

    11.     Zhen-yuan Gu, Qin-chao Xu, Guo-wen Xing* Nitrobenzofurazan-based Fluorescent Probes. Prog. Chem., 2013, 25, 1302-1312.

    12.     Ya-juan Wang, Zhen-yuan Gu and Guo-wen Xing* Continuous fluorometric assay for sialidase activity and inhibition with conjugated polyelectrolytes. Chem. Asian J., 2012, 7(3), 489-492.

    13.     Zhen-yuan Gu, Jia-xin Zhang, Guo-wen Xing* N-Acetyl-5-N,4-O-oxazolidinone-protected sialyl sulfoxide: an a-selective sialyl donor with Tf2O/(Tol)2SO in dichloromethane. Chem. Asian J., 2012, 7(7), 1524-1528.

    14.     Jia Jia, Qin-chao Xu, Ri-chen Li, Xi Tang, Ying-fang He, Meng-yu Zhang, Yuan Zhang, Guo-wen Xing* Tetrahydroindazolone substituted 2-aminobenzamides as fluorescent probes: switching metal ion selectivity from zinc to cadmium by interchanging the amino and carbamoyl groups on the fluorophore. Org. Biomol. Chem., 2012, 10, 6279-6286.

    15.     Jia Jia, Xi Tang, Ying-fang He, Meng-yu Zhang, Guo-wen Xing* Recent progress in fluorescent probes for Zn2+/Cd2+ based on small organic molecules. Chin. J. Org. Chem., 2012, 32, 1803-1811.

    16.     Jia Jia, Zhen-yuan Gu, Ri-chen Li, Ming-hao Huang, Cai-shuang Xu, Yi-fei Wang, Guo-wen Xing,* Yun-sheng Huang* Design and synthesis of fluorescent sensors for zinc ion derived from 2-aminobenzamide. Eur. J. Org. Chem., 2011, 4609-4615.

    17.     Huai-Qiang Ju, Shao-Xiang Wang, Yang-Fei Xiang, Zhong Liu, Jin-Yun Liu, Zhen-Ping Chen, Fan-Li Zeng, Min Xia, Zong-Hua Liu, Guo-Wen Xing,* Sha-Yan Wang,* and Yi-Fei Wang.* BJ-B11, a novel Hsp90 inhibitor, induces apoptosis in human chronic myeloid leukemia K562 cells through the mitochondria-dependent pathway. Eur. J. Pharmacol., 2011, 666, 26-34.  

    18.     Ya-juan Wang, Jia Jia, Zhen-yuan Gu, Fen-fen Liang, Ri-chen Li, Ming-hao Huang, Cai-shuang Xu, Jia-xin Zhang, Yi Men, Guo-wen Xing* Tunable Stereoselectivity during Sialylation of N-Acetyl-5-N,4-O-Oxazolidinone-Protected p-Toluene 2-Thiosialoside with Tf2O/Ph2SO/TTBPy. Carbohydr. Res., 2011, 346, 1271-1276.

    19.     Huai-Qiang Ju, Yang-Fei Xiang, Bao-Juan Xin, Ying Pei, Jia-Xin Lu, Qiao-Li Wang, Min Xia, Chui-Wen Qian, Zhe Ren, Sha-Yan Wang, Yi-Fei Wang*, Guo-Wen Xing* Synthesis and in vitro anti-HSV-1 activity of a novel Hsp90 inhibitor BJ-B11. Bioorg. Med. Chem. Lett., 2011, 21, 1675-1677.

    20.    Ya-juan Wang, Guo-wen Xing* Progress in Structure, Function and Catalytic Reactions of Sialidase and Sialyltransferase. Chin. J. Org. Chem., 2011, 31, 1157-1168.

     


 
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