发布时间: 2015-12-31 浏览次数:
讲授课程放射性药物化学基础,放射性药物化学实验,化学基础实验1,放射性药物与分子影像
研究兴趣放射性药物、分子探针与分子影像
主持项目
1. 2012.1-2015.12,国家自然科学基金青年项目 2. 2014.1-2015.6,北京市自然科学基金预探索项目 3. 2014.1-2017.12,国家重大新药创制子课题 4. 2016.1-2019.12,国家自然科学基金面上项目 5. 2018.1-2020.12,北京市自然科学基金面上项目 6. 2020.1-2023.12,国家自然科学基金联合基金重点项目 7. 2021.1-2023.12,国家自然科学基金优秀青年基金项目
代表性论文 Zhou, Kaixiang; Yuan, Chang; Dai, Bin; Wang, Kan; Chen, Yimin; Ma, Denglei; Dai, Jiapei; Liang, Yi*; Tan, Hongwei*; Cui, Mengchao*, Environment-Sensitive Based Near-Infrared Probe for Fluorescent Discrimination of Aβ and Tau Fibrils in AD Brain, J. Med. Chem., 2019, 62(14): 6694-6704
Zhang, Xiaoyang; Hou, Yaqin; Peng, Cheng; Wang, Chu; Wang, Xiang; Liang, Zhigang*; Lu, Jing; Chen, Baian*; Dai, Jiapei; Liu, Boli; Cui, Mengchao*, Oligoethyleneoxy-Modified 99mTc-Labeled β‑Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography, J. Med. Chem., 2018, 61(3): 1330-1339 Fu, Hualong; Cui, Mengchao*; Zhao, Liu; Tu, Peiyu; Zhou, Kaixiang; Dai, Jiapei; Liu, Boli, Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-beta Plaques in Alzheimer's Disease, J. Med. Chem., 2015, 58(17): 6972-6983 Yang, Yanping; Cui, Mengchao*; Zhang, Xiaoyang; Dai, Jiapei; Zhang, Zhiyong; Lin, Chunping; Guo, Yuzhi; Liu, Boli, Radioiodinated Benzyloxybenzene Derivatives: A Class of Flexible Ligands Target to β-Amyloid Plaques in Alzheimer's Brains, J. Med. Chem., 2014, 57(14): 6030-6042 Li, Zijing; Cui, Mengchao*; Dai, Jiapei; Wang, Xuedan; Yu, Pingrong; Yang, Yanping; Jia, Jianhua; Fu, Hualong; Ono, Masahiro; Jia, Hongmei; Saji, Hideo; Liu, Boli*, Novel Cyclopentadienyl Tricarbonyl Complexes of Tc-99m Mimicking Chalcone as Potential Single-Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Brain, J. Med. Chem., 2013, 56(2): 471-482 Cui, Mengchao; Ono, Masahiro*; Kimura, Hiroyuki; Ueda, Masashi; Nakamoto, Yuji; Togashi, Kaori; Okamoto, Yoko; Ihara, Masafumi; Takahashi, Ryosuke; Liu, Boli; Saji, Hideo, Novel F-18-Labeled Benzoxazole Derivatives as Potential Positron Emission Tomography Probes for Imaging of Cerebral β-Amyloid Plaques in Alzheimer's Disease, J. Med. Chem., 2012, 55(21): 9136-9145 Cui, Mengchao*; Wang, Xuedan; Yu, Pingrong; Zhang, Jinming; Li, Zijing; Zhang, Xiaojun; Yang, Yanping; Ono, Masahiro; Jia, Hongmei; Saji, Hideo; Liu, Boli*, Synthesis and Evaluation of Novel F-18 Labeled 2-Pyridinylbenzoxazole and 2-Pyridinylbenzothiazole Derivatives as Ligands for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques, J. Med. Chem., 2012, 55(21): 9283-9296. (Cover Article) Cui, Mengchao; Ono, Masahiro*; Kimura, Hiroyuki; Liu, Boli; Saji, Hideo*, Synthesis and Structure-Affinity Relationships of Novel Dibenzylideneacetone Derivatives as Probes for β-Amyloid Plaques, J. Med. Chem., 2011, 54(7): 2225-2240
授权专利202010182851.8靶向PSMA的双苯并噻二唑类化合物及其制备方法与应用 201910007703.X与Aβ蛋白和Tau蛋白具有高亲和力的双腙类化合物及其衍生物与应用 201811565327.8一种氟硼二吡咯类衍生物及其制备方法和用途 201710702980.3用于生物正交反应的1,2,4,5‑四嗪化合物及其制备方法与应用 201711144219.9与Tau蛋白具有亲和力的2-芳基喹喔啉类化合物及其制备方法与应用 201710474957.3与Aβ斑块具有高亲和力的二苯氧基柔性分子及其制备方法和应用 201410307344.7与Aβ斑块和神经纤维缠结具有亲和力的化合物及制备方法 201310447043.X与Aβ斑块具有高亲和力的2-芳基苯并噻唑类化合物、其制备方法及应用 US 9,809,585 B2 Fluorinated 2-arylbenzo heterocyclic compound with high affinity to Aβ plaques and containing chiral side chain substituent, and preparation method and usage thereof WO/2013/027694 Molecular imaging probes for diagnosing conformation disease
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